Objectives: Quantifying the combined impact of morbidity and mortality is a key enabler to assessing the impact of COVID-19 across countries and within countries relative to other diseases, regions, or demographics. Differences in methods, data sources, and definitions of mortality due to COVID-19 may hamper comparisons. We describe efforts to support countries in estimating the national-level burden of COVID-19 using disability-adjusted life years.

Methods: The European Burden of Disease Network developed a consensus methodology, as well as a range of capacity-building activities to support burden of COVID-19 studies. These activities have supported 11 national studies so far, with study periods between January 2020 and December 2021.

Results: National studies dealt with various data gaps and different assumptions were made to face knowledge gaps. Still, they delivered broadly comparable results that allow for interpretation of consistencies, as well as differences in the quantified direct health impact of the pandemic.

Discussion: Harmonized efforts and methodologies have allowed for comparable estimates and communication of results. Future studies should evaluate the impact of interventions, and unravel the indirect health impact of the COVID-19 crisis.


© 2022 Pires, Wyper, Wengler, Peñalvo, Haneef, Moran, Cuschieri, Redondo, De Pauw, McDonald, Moon, Shedrawy, Pallari, Charalampous, Devleesschauwer and Von Der Lippe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/

Cite as

Pires, S., Wyper, G., Wengler, A., Peñalvo, J., Haneef, R., Moran, D., Cuschieri, S., Redondo, H., de Pauw, R., McDonald, S., Moon, L., Shedrawy, J., Pallari, E., Charalampous, P., Devleesschauwer, B. & Von der Lippe, E. 2022, 'Burden of Disease of COVID-19: Strengthening the Collaboration for National Studies', Frontiers in Public Health, 10, article no: 907012. https://doi.org/10.3389/fpubh.2022.907012

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Last updated: 25 July 2022
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