- Published
- 01 July 2020
- Journal article
COVID-19 meets cystic fibrosis: for better or worse?
- Authors
- Source
- Genes and Immunity
Abstract
Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.
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Cite as
Peckham, D., McDermott, M., Savic, S. & Mehta, A. 2020, 'COVID-19 meets cystic fibrosis: for better or worse?', Genes and Immunity, 21(4), pp. 260-262. https://doi.org/10.1038/s41435-020-0103-y