Male sex has emerged as a major independent risk factor for severe disease and death from severe acute respiratory syndrome coronavirus–related coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 infects cells via the angiotensin converting enzyme 2 (ACE2) receptor, a widely distributed cell-surface receptor. In 2 cohorts of patients with heart failure (BIOSTAT-CHF [Biology Study to Tailored Treatment in Chronic Heart Failure]), we recently showed that age-adjusted plasma concentrations of ACE2 are higher in men than in women.


This content is not covered by the Open Government Licence. Please see source record or item for information on rights and permissions.

Cite as

Nelson, C., Sama, I., Codd, V., Webb, T., Ye, S., Lang, C., Voors, A., Ng, L. & Samani, N. 2020, 'Genetic associations with plasma angiotensin converting enzyme 2 concentration: Potential relevance to COVID-19 risk', Circulation, 142(11), pp. 1117-1119. https://doi.org/10.1161/CIRCULATIONAHA.120.049007

Downloadable citations

Download HTML citationHTML Download BIB citationBIB Download RIS citationRIS
Last updated: 17 June 2022
Was this page helpful?