SARS-CoV-2 vaccines administered in the UK are highly effective in preventing hospitalisation and death from COVID-19. Patients with immunocompromise are less likely to be able to mount a satisfactory immunological response to the vaccine and therefore may remain at higher risk of moderate-to-severe COVID-19. Understanding the reasons and risk-factors for admission will provide insight into strategies for future vaccination. This study aimed to characterise the hospitalised vaccinated population and identify the effect of the relationship between vaccination status and immunocompetence on hospital mortality using the prospective observational cohort recruited from the UK Coronavirus Clinical Information Network (CO-CIN).


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Egan, C., Turtle, L., Thorpe, M., Harrison, E., Semple, M., Docherty, A. & ISARIC4C Investigators 2022, 'Hospital admission for symptomatic COVID-19 and impact of vaccination: Analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service', Anaesthesia, 77(5), pp. 605-608. https://doi.org/10.1111/anae.15677

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Last updated: 19 August 2023
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