This study is to estimate in-hospital mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients stratified by hemoglobin (Hb) level. Patients were stratified according to hemoglobin level into two groups, that is, Hb <100 g/L and Hb >100 g/L. A total of 6931 patients were included. Of these, 6377 (92%) patients had hemoglobin levels >100 g/L. The mean age was 44 ± 17 years, and 66% of the patients were males. The median length of overall hospital stay was 13 days [2; 31]. The remaining 554 (8%) patients had a hemoglobin level <100 g/L. Overall mortality was 176 patients (2.54%) but was significantly higher in the group with hemoglobin levels <100 g/L (124, 22.4%) than in the group with hemoglobin levels >100 g/L (52, 0.82%). Risk factors associated with increased mortality were determined by multi- variate analysis. The Kaplan-Meier survival analysis showed hemoglobin as a predictor of mortality. Cox proportional hazards regression coefficients for hemoglobin for the HB ≤ 100 category of hemoglobin were significant, B = 2.79, SE = 0.17, and HR = 16.34, p < 0.001. Multivariate logistic regression showed Hb < 100 g/L had a higher cumu- lative all-cause in-hospital mortality (22.4% vs. 0.8%; adjusted odds ratio [aOR], 0.33; 95% [CI]: [0.20–0.55]; p < 0.001). In this study, hemoglobin levels <100 g/L were found to be an independent predictor of in-hospital mortality.


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Al-Jarallah, M., Rajan, R., Al Saber, A., Pan, J., TAl-Sultan, A., Abdelnaby, H., Alroomi, M., Dashti, R., Aboelhassan, W., Almutairi, F., Abdullah, M., Alotaibi, N., Al Saleh, M., AlNasrallah, N., Al-Bader, B., Malhas, H., Ramadhan, M., Hamza, M. & Zhanna, K. 2021, 'In-hospital mortality in SARS-CoV-2 stratified by hemoglobin levels : a retrospective study', eJHaem, 193(5), pp. 857-1016. https://doi.org/10.1002/jha2.195

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Last updated: 03 September 2022
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