A striking feature of severe forms of coronavirus disease 2019 (COVID-19), the current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is severe endothelial injury with micro- and macrothrombotic disease in the lung and other organs, including the heart. This has led to speculation that viral infection may damage the endothelium through 2 mechanisms: indirectly, via neighborhood effects, circulating mediators, and immune mechanisms or directly by viral infection of endothelial cells (ECs).


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McCracken, I., Saginc, G., He, L., Huseynov, A., Daniels, A., Fletcher, S., Peghaire, C., Kalna, V., Andaloussi-mäe, M., Muhl, L., Craig, N., Griffiths, S., Haas, J., Tait-Burkard, C., Lendahl, U., Birdsey, G., Betsholtz, C., Noseda, M., Baker, A. & Randi, A. 2021, 'Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells', Circulation, 143(8), pp. 865-868. https://doi.org/10.1161/CIRCULATIONAHA.120.052824

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Last updated: 02 June 2023
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