- Published
- 06 January 2022
- Journal article
Lineage replacement and evolution captured by the United Kingdom Covid Infection Survey
- Authors
-
- Source
- medRxiv
Abstract
The Office for National Statistics COVID-19 Infection Survey is a large household-based surveillance study based in the United Kingdom. Here, we report on the epidemiological and evolutionary dynamics of SARS-CoV-2 determined by analysing sequenced samples collected up until 13th November 2021. We observed four distinct sweeps or partial-sweeps, by lineages B.1.177, B.1.1.7/Alpha, B.1.617.2/Delta, and finally AY.4.2, a sublineage of B.1.617.2, with each sweeping lineage having a distinct growth advantage compared to their predecessors. Evolution was characterised by steady rates of evolution and increasing diversity within lineages, but with step increases in divergence associated with each sweeping major lineage, leading to a faster overall rate of evolution and fluctuating levels of diversity. These observations highlight the value of viral sequencing integrated into community surveillance studies to monitor the viral epidemiology and evolution of SARS-CoV-2, and potentially other pathogens, particularly as routine PCR testing is phased out or in settings where large-scale sequencing is not feasible.
Rights
The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. http://creativecommons.org/licenses/by-nc-nd/4.0/
Cite as
Lythgoe, K., Golubchik, T., Hall, M., House, T., MacIntyre-Cockett, G., Fryer, H., Thomson, L., Nurtay, A., Buck, D., Green, A., Trebes, A., Piazza, P., Lonie, L., Studley, R., Rourke, E., Cook, D., Smith, D., Bashton, M., Nelson, A., Crown, M., McCann, C., Young, G., dos Santos, R., Richards, Z., Tariq, A., Wellcome Sanger Institute COVID-19 Surveillance Team, COVID-19 Infection Survey Group, The COVID-19 Genomics UK (COG-UK) Consortium, Fraser, C., Diamond, I., Barrett, J., Walker, S. & Bonsall, D. 2022, 'Lineage replacement and evolution captured by the United Kingdom Covid Infection Survey'. To be published in MedRxiv [Preprint]. Available at: https://doi.org/10.1101/2022.01.05.21268323