This prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n=748). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]) in physically active patients and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full-course of an inactivated SARS-CoV-2 vaccine.


This item is under embargo in the Robert Gordon University Repository until Jul 18, 2023 due to copyright reasons. Contact publications@rgu.ac.uk to request a copy for personal use.

Cite as

Gualano, B., Lemes, Í., da Silva, R., Pinto, A., Mazzolani, B., Smaira, F., Sieczkowska, S., Aikawa, N., Pasoto, S., Medeiros-Ribeiro, A., Saad, C., Yuk, E., Silva, C., Swinton, P., Hallal, P., Roschel, H. & Bonfa, E. 2022, 'Physical activity and antibody persistence 6 months after the second dose of coronavac in immunocompromised patients.', Scandinavian Journal of Medicine and Science in Sports. https://doi.org/10.1111/sms.14213

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Last updated: 23 November 2023
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