- Published
- 01 September 2020
- Journal article
Predicting severe outcomes in COVID-19
- Authors
- Source
- The Journal of Allergy and Clinical Immunology: In Practice
Abstract
SARS-CoV2 infection enters via the nose and, after aspiration to the lower respiratory tract, may then rapidly involve the lungs, resulting in severe hypoxic pneumonia. In the later stage of coronavirus disease 2019 (COVID-19), there is also a cytokine-mediated hyperinflammatory response and coagulopathy, which in many respects simulates a viral-induced multiorgan autoimmune response.
Patients who tend to fare worse with more severe outcomes are males, elderly, smokers, black and Asian people, those with obesity, along with the presence of comorbidities such as diabetes, hypertension, chronic heart, lung and kidney disease, dementia, neoplasia, and immunosuppression.
Rights
© 2020 American Academy of Allergy, Asthma & Immunology
Cite as
Lipworth, B., Chan, R. & Kuo, C. 2020, 'Predicting severe outcomes in COVID-19', The Journal of Allergy and Clinical Immunology: In Practice, 8(8), pp. 2582-2584. https://doi.org/10.1016/j.jaip.2020.06.039