The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.


© 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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Bahadur, G., Acharya, S., Muneer, A., Huirne, J., Łukaszuk, M., Doreski, P. & Homburg, R. 2020, 'SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility', Reproductive BioMedicine Online, 41(3), pp. 3365-3369. http://dx.doi.org/10.1016/j.rbmo.2020.05.014

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Last updated: 17 June 2022
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