- Published
- 06 August 2024
- Journal article
Selecting the most informative positive and negative controls for self-controlled case series (SCCS): rationale, approach, and lessons from studies investigating the safety of COVID-19 vaccines
- Authors
- Source
- Journal of Global Health
Full text
Abstract
The self-controlled case series (SCCS) is a study design used in epidemiology to test for variation in outcomes for a group of individuals before and after an exposure or intervention, with each pre-intervention individual serving as a control for themselves in the post-intervention period. The design is particularly useful for studying rare events or outcomes that occur in a time-dependent manner, such as uncommon side-effects of a medical intervention [1–3]. In the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) study, we used this SCCS design to evaluate the safety of coronavirus disease 2019 (COVID-19) vaccines in various age groups of the Scottish and UK populations.
Rights
This content is not covered by the Open Government Licence. Please see source record or item for information on rights and permissions.
Cite as
Rudan, I., Katikireddi, S., Kerr, S., Millington, T., Grange, Z., Sullivan, C., Fagbamigbe, A., Swallow, B., Kurdi, A., Morrison, K., Jeffrey, K., Simpson, C., Robertson, C., Ritchie, L. & Sheikh, A. 2024, 'Selecting the most informative positive and negative controls for self-controlled case series (SCCS): rationale, approach, and lessons from studies investigating the safety of COVID-19 vaccines', Journal of Global Health, 14, article no: 03037. https://doi.org/10.7189/jogh.14.03037
Downloadable citations
Download HTML citationHTML Download BIB citationBIB Download RIS citationRISIdentifiers
- Repository URI
- https://strathprints.strath.ac.uk/90189/