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https://doi.org/10.1111/php.13798 10.1111/php.13798


The highly transmittable nature of SARS-CoV-2 has increased the necessity for novel strategies to safely decontaminate public areas. This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Bacteriophage phi6 was exposed to increasing doses of low irradiance (~0.5 mW cm-2) 405-nm light whilst suspended in SM buffer and artificial human saliva at low (~103-4 PFU mL-1) and high (~107-8 PFU mL-1) seeding densities, to determine system efficacy for SARS-CoV-2 inactivation and establish the influence of biologically-relevant suspension media on viral susceptibility. Complete/near-complete (≥99.4%) inactivation was demonstrated in all cases, with significantly enhanced reductions observed in biologically-relevant media (P

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Sinclair, L., Ilieva, Z., Morris, G., Anderson, J., MacGregor, S. & Maclean, M. 2023, 'Viricidal efficacy of a 405-nm environmental decontamination system for inactivation of bacteriophage Phi6: surrogate for SARS-CoV-2', Photochemistry and Photobiology. https://doi.org/10.1111/php.13798 10.1111/php.13798

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Last updated: 20 March 2023
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