- Published
- 23 July 2020
- Journal article
The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study
- Authors
-
- Source
- Cardiovascular Research
Full text
Abstract
Background: COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods: This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion: CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.
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This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.
Cite as
Mangion, K., Morrow, A., Bagot, C., Bayes, H., Blyth, K., Church, C., Corcoran, D., Delles, C., Gillespie, L., Grieve, D., Ho, A., Kean, S., Lang, N., Lennie, V., Lowe, D., Kellman, P., Macfarlane, P., McConnachie, A., Roditi, G., Sykes, R., Touyz, R., Sattar, N., Wereski, R., Wright, S. & Berry, C. 2020, 'The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study', Cardiovascular Research, 116(14), pp. 2185-2196. http://dx.doi.org/10.1093/cvr/cvaa209
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- Repository URI
- http://eprints.gla.ac.uk/219875/