Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?

Authors: Dockrell, David H. ;

Russell, Clark D. ;

McHugh, Brian;

Fraser, Rupsha

Source: European Respiratory Journal

Full text

: https://doi.org/10.1183/13993003.01521-2022

Abstract

SARS-CoV-2 has caused devastating effects with over 550 million infections by July 2022 and approximately 6.4 million deaths. Societal and economic impacts will reverberate for years, with continuous evolution of SARS-CoV-2 as it persistently spreads through the human population as exemplified by reduced activity of vaccines and monoclonals against Omicron BA.4 or BA.5 subvariants. A greater understanding of pathogenesis and more tailored therapeutic approaches are therefore essential.

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Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

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Dockrell, D., Russell, C., McHugh, B. & Fraser, R. 2022, 'Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?', European Respiratory Journal. https://doi.org/10.1183/13993003.01521-2022

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DOI: https://doi.org/10.1183/13993003.01521-2022

Repository URI: https://www.research.ed.ac.uk/en/publications/828e579f-4a89-4cf2-bbfe-d75975e7cbc0