A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention

Authors: Hamis, Sara J. ;

Macfarlane, Fiona R.

Source: AIMS Mathematics

Full text

: https://doi.org/10.3934/math.2021356

Abstract

SJH is supported by the Medical Research Council grant MR/R017506/1. The authors would like to thank the SARS-CoV-2 Tissue Simulation Coalition for ongoing collaboration and feedback on model development. Further, this work is part of the RAMP (Rapid Assistance in Modelling the Pandemic) initiative, coordinated by the Royal Society, UK. The authors would like to thank Prof. Mark A.J. Chaplain (University of St Andrews) for coordinating our RAMP Task Team modelling within-host dynamics. SARS-CoV-2 Tissue Simulation Coalition: http://physicell.org/covid19/. RAMP: https://royalsociety.org/topics-policy/health-and-wellbeing/ramp/.

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Copyright © 2021 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).

Cite as

Hamis, S. & Macfarlane, F. 2021, 'A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention', AIMS Mathematics, 6(6), pp. 6050-6086. https://doi.org/10.3934/math.2021356

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DOI: https://doi.org/10.3934/math.2021356

Repository URI: http://hdl.handle.net/10023/23024