Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19:A case study in affinity predictions of interface variants

Authors: MacGowan, Stuart A. ;

Barton, Michael Ian;

Kutuzov, Mikhail;

Dushek, Omer;

van der Merwe, P. Anton ;

Barton, Geoffrey J.

Source: PLoS Computational Biology

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: https://doi.org/10.1371/journal.pcbi.1009922

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This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MacGowan, S., Barton, M., Kutuzov, M., Dushek, O., van der Merwe, P. & Barton, G. 2022, 'Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19:A case study in affinity predictions of interface variants', PLoS Computational Biology, 18(3), article no: e1009922. https://doi.org/10.1371/journal.pcbi.1009922

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DOI: https://doi.org/10.1371/journal.pcbi.1009922

Repository URI: https://discovery.dundee.ac.uk/en/publications/61d47368-fc55-412b-b3e6-0c49ca8a85e4