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Showing 9 results

From a single sequence to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 protein sequences

Author

Lamb, Kieran D.; Hughes, Joseph; Lytras, Spyros; Young, Francesca; Koci, Orges; Herzig, James; Lovell, Simon C.; Grove, Joe; Yuan, Ke; Robertson, David L.

Source

bioRxiv

Type

Journal article

Published

18 September 2024
Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response

Author

Nyirenda, James; Hardy, Olympia; da Silva Filho, João; Herder, Vanessa; Attipa, Charalampos; Ndovi, Charles; Siwombo, Memory; Namalima, Takondwa; Suwedi, Leticia; Nyasulu, Watipenge and 36 others

Source

bioRxiv

Type

Journal article

Published

12 December 2023
The SARS-CoV-2 envelope (E) protein forms a calcium-and voltage-activated calcium channel [pre-print]

Author

Antonides, Lysbeth H.; Hurst, Quenton W.; Ives, Callum M.; Ramberg, Kiefer; Ostrovitas, Nikitas; Scanlan, Eoin; Caffrey, Martin; Pitt, Samantha J.; Zachariae, Ulrich

Source

BioRxiv

Type

Journal article

Published

11 October 2022
Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

Author

Willett, Brian J.; Kurshan, Ashwini; Thakur, Nazia; Newman, Joseph; Manali, Maria; Tyson, Grace B.; Logan, Nicola; Murcia, Pablo R.; Snell, Luke; Edgeworth, Jonathan D. and 11 others

Source

BioRxiv

Type

Journal article

Published

25 May 2022
Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike

Author

MacGowan, Stuart A.; Barton, Michael Ian; Kutuzov, Mikhail; Dushek, Omer; van der Merwe, P. Anton; Barton, Geoffrey J.

Source

BioRxiv

Type

Journal article

Published

21 May 2021
Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

Author

Sziemel, Agnieszka M.; Hwa, Shi-Hsia; Sigal, Alex; Tyson, Grace B.; Logan, Nicola; Willett, Brian J.; Durcan, Peter J.

Source

BioRxiv

Type

Journal article

Published

12 April 2021
Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2 [pre-print]

Author

Jeffreys, Laura N.; Pennington, Shaun H.; Duggan, Jack; Breen, Alastair F.; Jinks, Jessica B.; Ardrey, Alison; Donnellan, Samantha; Patterson, Edward I.; Hughes, Grant L.; Hong, David W. and 5 others

Source

International Journal of Antimicrobial Agents

Type

Journal article

Published

24 December 2020
Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design [Preprint]

Author

Berta, Dénes; Badaoui, Magd; Buigues, Pedro J.; Martino, Sam Alexander; Pisliakov, Andrei V.; Elghobashi-Meinhardt, Nadia; Wells, Geoff; Harris, Sarah A.; Frezza, Elisa; Rosta, Edina

Type

Journal article

Published

03 November 2020
Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19

Author

MacGowan, Stuart A.; Barton, Geoffrey J.

Source

BioRxiv

Type

Journal article

Published

04 May 2020

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