Background: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and COVID-19. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.

Methods: We conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: i) diagnosed with COVID-19, ii) hospitalized with COVID-19, and iii) hospitalized with influenza in 2017-2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.

Results: We included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5-19% and 1-14% in the diagnosed cohort, respectively). Hematological malignancies were also frequent, with non-Hodgkin's lymphoma being among the 5 most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n=67,743) had a similar distribution of cancer subtypes, sex, age and comorbidities but lower occurrence of adverse events.

Conclusions: Patients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematological malignancies were frequent.

Impact: This study provides epidemiologic characteristics that can inform clinical care and etiological studies.


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Cite as

Roel, E., Pistillo, A., Recalde, M., Sena, A., Fernández-Bertolín, S., Aragón, M., Puente, D., Ahmed, W., Alghoul, H., Alser, O., Alshammari, T., Areia, C., Blacketer, C., Carter, W., Casajust, P., Culhane, A., Dawoud, D., DeFalco, F., DuVall, S., Falconer, T., Golozar, A., Gong, M., Hester, L., Hripcsak, G., Tan, E., Jeon, H., Jonnagaddala, J., Lai, L., Lynch, K., Matheny, M., Morales, D., Natarajan, K., Nyberg, F., Ostropolets, A., Posada, J., Prats-Uribe, A., Reich, C., Rivera, D., Schilling, L., Soerjomataram, I., Shah, K., Shah, N., Shen, Y., Spotnitz, M., Subbian, V., Suchard, M., Trama, A., Zhang, L., Zhang, Y., Ryan, P., Prieto-Alhambra, D., Kostka, K. & Duarte-Salles, T. 2021, 'Characteristics and outcomes of over 300,000 COVID-19 individuals with history of cancer in the United States and Spain', Cancer Epidemiology, Biomarkers and Prevention. https://doi.org/10.1158/1055-9965.EPI-21-0266

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Last updated: 14 September 2022
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