The first EULAR provisional recommendations on the management of rheumatic and musculoskeletal diseases (RMDs) in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), largely based on expert opinion, were published in June 2020. Since then, an unprecedented number of clinical studies have accrued in the literature. Several SARS-CoV-2 vaccines have been approved for population-wide vaccination programmes in EULAR-affiliated countries. Studies regarding vaccination of patients with (inflammatory) RMDs have released their first results or are underway.

EULAR found it opportune to carefully review to what extent the initially consensus expert recommendations stood the test of time, by challenging them with the recently accumulated body of scientific evidence, and by incorporating evidence-based advice on SARS-CoV-2 vaccination. EULAR started a formal (first) update in January 2021, performed a systematic literature review according to EULAR's standard operating procedures and completed a set of updated overarching principles and recommendations in July 2021. Two points to consider were added in November 2021, because of recent developments pertaining to additional vaccination doses.


No commercial re-use. See rights and permissions on BMJ website.

Cite as

Landewé, R., Kroon, F., Alunno, A., Najm, A., Bijlsma, J., Burmester, G., Caporali, R., Combe, B., Conway, R., Curtis, J., Elkayam, O., Gossec, L., Heijstek, M., Haupt, L., Iagnocco, A., Isaacs, J., Juhász, I., Makri, S., Mariette, X., McInnes, I., Mehta, P., Mueller-Ladner, U., Schulze-Koops, H., Smolen, J., Wiek, D., Winthrop, K., Navarro-Compán, V. & Machado, P. 2022, 'EULAR recommendations for the management and vaccination of people with rheumatic and musculoskeletal diseases in the context of SARS-CoV-2: the November 2021 update.', Annals of the Rheumatic Diseases. http://dx.doi.org/10.1136/annrheumdis-2021-222006

Downloadable citations

Download HTML citationHTML Download BIB citationBIB Download RIS citationRIS
Last updated: 16 June 2022
Was this page helpful?