Ferritin level: a predictor of severity and mortality in hospitalized COVID-19 patients

Authors: Alroomi, Moudhi ;

Rajan, Rajesh ;

Omar, Abdulaziz A.;

Alsaber, Ahmad R. ;

Pan, Jiazhu;

Fatemi, Mina;

Zhanna, Kobalava D.;

Aboelhassan, Wael;

Almutairi, Farah;

Alotaibi, Naser;

Saleh, Mohammad A.;

AlNasrallah, Noor;

Al-Bader, Bader;

Malhas, Haya;

Ramadhan, Maryam;

Abdullah, Mohammed;

Abdelnaby, Hassan

Source: Immunity, Inflammation and Disease

Full text

: https://doi.org/10.1002/iid3.517

Abstract

Introduction: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.

Methods: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).

Results: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p <.001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p =.003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p <.001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p <.001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000.

Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

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This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cite as

Alroomi, M., Rajan, R., Omar, A., Alsaber, A., Pan, J., Fatemi, M., Zhanna, K., Aboelhassan, W., Almutairi, F., Alotaibi, N., Saleh, M., AlNasrallah, N., Al-Bader, B., Malhas, H., Ramadhan, M., Abdullah, M. & Abdelnaby, H. 2021, 'Ferritin level: a predictor of severity and mortality in hospitalized COVID-19 patients', Immunity, Inflammation and Disease, pp. 1-8. https://doi.org/10.1002/iid3.517

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DOI: https://doi.org/10.1002/iid3.517

Repository URI: https://strathprints.strath.ac.uk/77474/