Introduction To investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait. Methods A retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction. Results A total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6). Conclusion Type 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.
Al-Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., Alsaeed, D., Al Ozairi, A., Hasan, A., Al-Mulla, F., Katikireddi, S., Gray, S., Gill, J., Celis-Morales, C., Sattar, N. & Welsh, P. 2021, 'Risk of mortality among inpatients with COVID-19 and type 2 diabetes: national data from Kuwait', Endocrinology, Diabetes and Metabolism, article no: e00287. https://doi.org/10.1002/edm2.287